The USAID and Australia Mekong Safeguards Program (Mekong Safeguards) is a jointly funded initiative between the United States Agency for International Development (USAID) and the Australia Department of Foreign Affairs and Trade (DFAT).

Its shared mission is to accelerate the sustainable infrastructure transition in the Mekong Region by reducing negative environmental and social impacts of large-scale energy and transport projects in Cambodia, Lao PDR, Myanmar, Thailand, and Vietnam. Mekong Safeguards strengthens environmental, social, and corporate governance standards (ESG) at the local, national, and transboundary levels by engaging governments, banks, and communities.